Linette Castillo

Assistant Professor
Ph.D., 2011; UPR-MSC

Academic Department(s)
Pathology and Laboratory Medicine

Research Area
Breast Cancer

Research Interest
Novel Therapeutics Against Aggressive Breast Cancers

Selected Publications
The addition of a pregnenolone pendant group enhances the anticancer properties of titanocene dichloride in a mcf-7 xenograft model.  Ramos G, Loperena Y, Ortiz G, Reyes F, Szeto A, Vera J, Vélez J, Morales J, Morrero D, Castillo L, Dharmawardhane S, Melendez E, Washington AV.  Anticancer Res. 2014 Apr;34(4):1609-15
Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Castillo-Pichardo, L, Dharmawardhane, S. Nutrition and Cancer, 2012, 64(7):1058-69.
Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised miceCastillo-Pichardo, L., Cubano, L., Dharmawardhane, S. BMC Complement Altern Med. 2013 Jan 8:13:6.
Characterization of EHop-016, a novel small molecule inhibitor of Rac GTPase.  Montalvo-Ortiz, BL, Castillo-Pichardo, L, Hernández E, Humpries-Bicley, T, De la Mota-Peynado, A, Cubano, LA, Vlaar CP, Dharmawardhane, S. Journal of Biological Chemistry, 2012, 287 (16):13228-38.
Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Castillo-Pichardo L, Martínez-Montemayor MM, Martínez JE, Wall KM, Cubano LA, Dharmawardhane S. Clin Exp Metastasis. 2009;26(6):505-16.

Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032