Linette Castillo

Assistant Professor
Ph.D., 2011; UPR-MSC

Academic Department(s)
Pathology and Laboratory Medicine

Research Area
Breast Cancer

Research Interest
Novel Therapeutics Against Aggressive Breast Cancers

Selected Publications
Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Castillo-Pichardo, L, Dharmawardhane, S. Nutrition and Cancer, 2012, 64(7):1058-69.
Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised miceCastillo-Pichardo, L., Cubano, L., Dharmawardhane, S. BMC Complement Altern Med. 2013 Jan 8:13:6.
Characterization of EHop-016, a novel small molecule inhibitor of Rac GTPase.  Montalvo-Ortiz, BL, Castillo-Pichardo, L, Hernández E, Humpries-Bicley, T, De la Mota-Peynado, A, Cubano, LA, Vlaar CP, Dharmawardhane, S. Journal of Biological Chemistry, 2012, 287 (16):13228-38.
Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Castillo-Pichardo L, Martínez-Montemayor MM, Martínez JE, Wall KM, Cubano LA, Dharmawardhane S. Clin Exp Metastasis. 2009;26(6):505-16.

Red wine Polyphenols Reduce Breast Tumor Growth in a Nude Mouse Model. Schlachterman A, Valle V, Wall K, Azios N, Castillo L, Morel L, Washington AV, Cubano L, Dharmawardhane S. Translational Oncology, 2008, 1(1), 19-27.

Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032