Linette Castillo

Assistant Professor
Ph.D., 2011; UPR-MSC
ORCID #0000-0003-4290-1774

Academic Department(s)
Pathology and Laboratory Medicine

Research Area
Breast Cancer

Research Interest
Novel Therapeutics Against Aggressive Breast Cancers
Dr. Castillo studies triple negative breast cancer (TNBC), an aggressive metastatic subtype with high mortality rates, commonly diagnosed in younger women and women of African-American descent. TNBCs often compensate for the loss of HER2 by overexpressing other epidermal growth factor receptor (EGFR or Her) family members such as EGFR1 (EGFR) and 3 (Her3) that have been correlated with poor survival in this breast cancer subtype. Therefore, dual targeting of EGFR and Her3 is a promising strategy for TNBC treatment. Students will be testing the effect of targeting EGFR and Her3 in TNBC cell lines.
Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032
Tel: 787-798-3001 ext. 2150