Linette Castillo

Assistant Professor
Ph.D., 2011; UPR-MSC
ORCID #0000-0003-4290-1774

Academic Department(s)
Pathology and Laboratory Medicine

Research Area
Breast Cancer

Research Interest
Novel Therapeutics for Metastatic Breast Cancer
 
Metastatic disease is the primary cause of breast cancer mortality, but effective treatments remain elusive. There is a critical need to develop efficient strategies to inhibit metastatic breast cancer. The Rho GTPase Rac is a key molecular switch activated by a myriad of cell surface receptors to promote cancer cell migration/invasion, proliferation, and survival. Metastatic breast cancers often overexpress or exhibit high Rac activity. Therefore, inhibition of Rac is a viable strategy to inhibit metastatic cancer progression. Students will be testing the effects and mechanism of action of Rac inhibitors on breast cancer cells and a mouse model of metastatic breast cancer.
 
Publications
 
http://www.ncbi.nlm.nih.gov/sites/myncbi/1FA5Ag6nojNAx/collections/46351910/public/ 
 
 
Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032
Tel: 787-798-3001 ext. 2150
e-mail: linnettecastillo@yahoo.com