Vesna Eterovic

Distinguished Research Professor
Ph.D. 1971, National Uni. of Cordoba, Argentina
ORCID #0000-0003-4556-2739

Academic Department(s)
Department of Biochemistry

Research Area
Neuroscience-Nicotinic acetylcholine receptor

Research Interest
The mechanism of how cembranoids block the muscle type acetylcholine receptor, with the purpose of contributing to a better understanding of the structure and function of this important prototype of all ligand-gated ion channels.

Dr. Eterovic current research focuses on the preclinical development of 4R-cembranoid, a first in class neuroprotective and antiinflammatory drug. Dr. Eterovic and collaborators demonstrated that 4R-cembranoid (4R), a compound isolated from tobacco, prevented neuronal death and displayed anti-inflammatory properties. Thus 4R is a promising source of therapeutics for many clinical areas, including stroke, Parkinson disease (PD), Alzheimer disease, AIDS and NeuroAIDS, and organophosphate poisoning (OP). These studies aim at establishing the 4R pharmacophore for neuroprotective activity, using in vitro models of OP, PD and stroke, natural and semisynthetic 4R analogues, and pharmacophore modeling. Since 4R target is the α7 nicotinic acetylcholine receptor, parallel studies endeavor to determine the 4R binding sites on this receptor using co-crystalization, site-directed mutagenesis, and patch-clamp electrophysiology.


Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032

Tel  (787) 798-3001 ext. 2032