Nawal Boukli

Associate Professor
Proteomics Facility Director
Ph.D. 2000, University of Geneva

Academic Department(s)
Microbiology and Immunology

Research Area
Cancer Biomarkers
HIV and Substance Abuse

Research Interest
HIV type B is more neurotoxic than type C affecting the human brain differently.  We are investigating molecular mechanism in human neurons that could explain this difference.

Anti-tumor activity of natural compounds in prostate, colon and pancreas cancer cell lines.

Selected Publications
Enhancement of NMDA Receptor-Mediated Excitatory Postsynaptic Currents by gp120-Treated Macrophages:  Implications for HIV-1-Associated Neuropathology.  Yang J, Hu D, Xia J, Liu J, Zhang G, Gendelman HE, Boukli NM, Xiong H. J Neuroimmune Pharmacol.  2013 Sep;8(4):921-33.

Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Mazzio EA, Boukli N, Rivera N, Soliman KF. Cancer Sci. 2012 Mar;103(3):422-32.

Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients. Boukli NM, Shetty V, Cubano L, Ricaurte M, Coelho-Dos-Reis J, Nickens Z, Shah P, Talal AH, Philip R, Jain P. Clin Proteomics. 2012 Sep 7;9(1):11.
Fasciola hepatica and Schistosoma mansoni: identification of common proteins by comparative proteomic analysis. Boukli NM, Delgado B, Ricaurte M, Espino AM. The Journal of Parasitology. 2011 Oct;97(5):852-61.

Implications of ER stress, the unfolded protein response, and Pro and anti-apoptotic protein fingerprints in human monocyte-derived dendritic cells treated with alcohol.  Boukli NM, Saiyed ZM, Ricaurte M, Rodriguez JW, Rios-Olivares E, Cubano LA, Nair MP. Alcohol Clin Exp Res.  2010 Dec;34(12)2081-8.

Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032

Tel (787) 798-3001  ext. 2080