Manu O. Platt

 

Adjunct Assistant Professor

Ph.D. 2006, Georgia Institute of Technology and Emory University

 

Academic Department(s)

Pathology and Laboratory Medicine

 

Research Area

 

Research Interest

Tissue remodeling in arteries due to sickle cell disease or HIV-infection, roles of proteases in tumor metastasis, and bone marrow-derived stem cell based therapies.

 

Publications

Barabino GA, Platt MO, Kaul DK. Sickle Cell Biomechanics. Annu Rev Biomed Eng. 2010 Aug 15;12:345-67. PubMed PMID: 20455701.

Li WA, Barry ZT, Cohen JD, Wilder CL, Deeds RJ, Keegan PM, Platt MO. Detection of femtomole quantities of mature cathepsin K with zymography. Anal Biochem. 2010 Mar 3. [Epub ahead of print] PubMed PMID: 20206119

Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells. 2009 Nov;27(11):2804-14. PubMed PMID: 19750537.

Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. J Cell Physiol. 2009 Nov;221(2):306-17. PubMed PMID: 19544388.

Platt MO, Ankeny RF, Shi GP, Weiss D, Vega JD, Taylor WR, Jo H. “Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis.” Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1479-86. Epub 2006 Nov 10.

Contact Information 

Universidad Central del Caribe

P.O. Box 60327

Bayamón, PR 00960-6032

 

Tel.: (787) 798-3001 

e-mail: