Manu O. Platt

Adjunct Assistant Professor
Ph.D. 2006, Georgia Institute of Technology and Emory University
Academic Department(s)
Pathology and Laboratory Medicine
Research Area
Research Interest
Tissue remodeling in arteries due to sickle cell disease or HIV-infection, roles of proteases in tumor metastasis, and bone marrow-derived stem cell based therapies.
Selected Publications
Sickle Cell Biomechanics. Barabino GA, Platt MO, Kaul DK.  Annu Rev Biomed Eng. 2010 Aug 15;12:345-67. 

Detection of femtomole quantities of mature cathepsin K with zymography. Li WA, Barry ZT, Cohen JD, Wilder CL, Deeds RJ, Keegan PM, Platt MO. Anal Biochem. 2010 Jun 1;401(1):91.8

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cellsPlatt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. S J Cell Physiol. 2009 Nov;221(2):306-17. 

“Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis.”  Platt MO, Ankeny RF, Shi GP, Weiss D, Vega JD, Taylor WR, Jo H.  Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1479-86. 

Contact Information 
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032
Tel.: (787) 798-3001