David R. Soto Pantoja

Adjunct Assistant Professor
Ph.D., 2008; Wake Forest University School of Medicine, Winston Salem, NC

Academic Department(s)
Department of Pathology and Laboratory Medicine
Research Area
Cancer Biology and Surgery/Hypertension
Research Interest
a) Regulation of the tumor microenvironment by the Thrombospondin-1/CD47 signaling axis.
b) Regulation of angiogenesis by thrombospondins
c) Role of autophagy and apoptosis in radioprotection of tissues.
d) Mechanisms of tumor resistance to radiation therapy/chemotherapy
Selected Publications
Therapeutic targeting of CD47 to modulate tissue responses to ischemia and radiation. Soto-Pantoja DR, Isenberg JS, Roberts DD.  Journal of Genetic Syndromes & Gene Therapy. 2011 Oct;2(2).
TSP-1. Soto-Pantoja DR & David D. Roberts.  Encyclopedia of Signaling Molecules.  Springer Science. In press.

Angiotensin Peptides and Lung Cancer. Gallagher PE, Cook K, Soto-Pantoja DR, Menon J, Tallant EA.  Current Cancer Drug Targets. 2011 May;11(4):394-404.

Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling.  Maxhimer JB,  Soto-Pantoja DR, Ridnour LA, Shih HB, Degraff WG, Tsokos M, Wink DA, Isenberg JS, Roberts DD. Science Translational Medicine. 2009 Oct 21;1(3):3ra7.

Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Soto-Pantoja DR, Menon J, Gallagher PE and Tallant EA.  Molecular Cancer Therapeutics. 2009 Jun;8 (6):1676-83. 
Contact Information
Wake Forest University
School of Medicine
Office: (336) 716-0792
Lab: (336) 713-4150
e-mail:  dsotopan@wakehealth.edu