David R. Soto Pantoja

 

Adjunct Assistant Professor

Ph.D., 2008; Wake Forest University School of Medicine, Winston Salem, NC

Academic Department(s)

Department of Pathology and Laboratory Medicine

 

Research Area

Cancer Biology / Radiation Oncology

 

Research Interest

a) Regulation of the tumor microenvironment by the Thrombospondin-1/CD47 signaling axis.

b) Regulation of angiogenesis by thrombospondins

c) Role of autophagy and apoptosis in radioprotection of tissues.

d) Mechanisms of tumor resistance to radiation therapy/chemotherapy

 

Publications

Soto-Pantoja DR, Isenberg JS, Roberts DD. Therapeutic targeting of CD47 to modulate tissue responses to ischemia and radiation. Journal of Genetic Syndromes & Gene Therapy. October 2011.

 

Soto-Pantoja DR & David D. Roberts. TSP-1. Encyclopedia of Signaling Molecules.  Springer Science. In press.

Gallagher PE, Cook K, Soto-Pantoja DR, Menon J, Tallant EA.  Angiotensin Peptides and Lung Cancer.  Current Cancer Drug Targets Volume 11, Number 4, May 2011

Maxhimer JB,  Soto-Pantoja DR, Ridnour LA, Shih HB, Degraff WG, Tsokos M, Wink DA, Isenberg JS, Roberts DD. Science Translational Medicine. 2009 Oct 21;1(3):3ra7.

Soto-Pantoja DR, Menon J, Gallagher PE and Tallant EA. Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Molecular Cancer Therapeutics. 2009 Jun;8 (6):1676-83. 2009 Jun 9.

 

 

Contact Information

Universidad Central del Caribe

P.O. Box 60327

Bayamón, PR 00960-6032

e-mail:  sotopantojadr@mail.nih.gov