Katherine L. Cook

Adjunct Assistant Professor
Ph.D., 2010, Wake Forest University Winston-Salem, NC

Academic Department(s)
Department of Pathology and Laboratory Medicine

Research Area
Breast Cancer and the Molecular Mechanisms of Therapeutic Resistance

Research Interest
(a)The role of the unfolded protein response in developing therapeutic resistance in breast cancer cells
(b) Determining the role of glucose regulated proteins (GRPs) in breast cancer
(c)Developing novel autophagy inhibitors to re-sensitize breast cancer cells to therapy
Selected Publications
Glucose-regulated protein 78 controls crosstalk between apoptosis and autophagy to determine antiestrogen responsiveness. Cook KL, Shajahan AS, Jin L, Wärri A, Hilakivi-Clarke L, and Clarke R. Cancer Res. 2012 Jul 1;72(13):3337-49.
Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate. Clarke R, Cook KL, Hu R, Facey CO, Tavasoly I, Schwartz JL, Bauman WT, Tyson JJ, Xuan J, Wang Y, Wärri A, Shajahan AN.  Cancer Res. 2012 Mar 15;72(6):1321-31.
Autophagy and Endocrine Resistance in Breast Cancer. Cook KL, Shajahan A, Clarke R. Expert Reviews in Anticancer Therapies. 11(8): 1283-1294, 2011. 
Angiotensin Peptides and Lung Cancer. Current Cancer Drug Targets.  Gallagher PE, Cook K, Soto-Pantoja D, Menon J, and Tallant EA. 11: 394-404, 2011.
Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Clarke R, Shajahan A, Wang Y, Tyson J, Riggins R, Weiner L, Bauman W, Xuan J,  Zhang B, Facey C, Aiyer H, Cook K, Hickman FE, Tavassoly I, Verdugo A, Chen C, Zwart A, Wärri A,and Hilakivi-Clarke L.  Hormone Molecular Biology and Clinical Investigation, 5: 35-44, 2011.

Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032
e-mail: klc74@georgetown.edu