Katherine L. Cook

 

Adjunct Assistant Professor

Ph.D., 2010, Wake Forest University Winston-Salem, NC

Academic Department(s)

Department of Pathology and Laboratory Medicine

Research Area

Breast Cancer and the Molecular Mechanisms of Therapeutic Resistance

Research Interest

(a)The role of the unfolded protein response in developing therapeutic resistance in breast cancer cells

(b) Determining the role of glucose regulated proteins (GRPs) in breast cancer

(c)Developing novel autophagy inhibitors to re-sensitize breast cancer cells to therapy

 

Publications

Cook KL, Shajahan AS, Jin L, Wärri A, Hilakivi-Clarke L, and Clarke R. Glucose-regulated protein 78 controls crosstalk between apoptosis and autophagy to determine antiestrogen responsiveness. (Submitted to Cancer Research January 2012)

 

Clarke R, Cook KL, Hu R, Facey C, Tavasoly I, Schwartz JL, Bauman WT, Tyson JJ, Xuan J, Wang Y, Wärri A, Shajahan AE. Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate. (In Press, Cancer Research March 2012) 

 

Cook KL, Shajahan A, Clarke R. Autophagy and Endocrine Resistance in Breast Cancer. Expert Reviews in Anticancer Therapies. 11(8): 1283-1294, 2011. 

 

Gallagher PE, Cook K, Soto-Pantoja D, Menon J, and Tallant EA. Angiotensin Peptides and Lung Cancer. Current Cancer Drug Targets. 11: 394-404, 2011.

 

Clarke R, Shajahan A, Wang Y, Tyson J, Riggins R, Weiner L, Bauman W, Xuan J,  Zhang B, Facey C, Aiyer H, Cook K, Hickman FE, Tavassoly I, Verdugo A, Chen C, Zwart A, Wärri A,and Hilakivi-Clarke L. Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer.  Hormone Molecular Biology and Clinical Investigation, 5: 35-44, 2011.

  

Contact Information

Universidad Central del Caribe

P.O. Box 60327

Bayamón, PR 00960-6032

e-mail: klc74@georgetown.edu