MBRS-SCORE

 

The Minority Biomedical Research Support (MBRS)- Support of Competitive Research (SCORE) at the Universidad Central del Caribe is funded and supported by the National Instituted of General Medical Sciences (NIGMS).

The purpose of MBRS-SCORE is to 1) increase the research competitiveness of investigators at UCC 2) to increase the numbers of underrepresented minority faculty, investigators, and students engaged in biomedical or behavioral research and 3) to broaden the opportunities for participation in biomedical or behavioral research of underrepresented minority faculty and students.

Links
SC1 PAR
SC2 PAR
SC3 PAR

 

Investigators
Richard Hann, Ph.D.
Analysis of Acetylcholine Receptor Subunit Residues Role in Assembly
Progress was made toward identifying structural features that control cell surface expression of two acetylcholine receptors, the muscle-type receptor and the human alpha 7 receptor. Alpha 7 and a chimeric receptor made from alpha 7 receptor and serotonin type 3A receptor have been established in the PI lab for the first time.

Legier Rojas, Ph.D. Synaptic
Remodeling and Thyroid Hormones
There is a deficit in our current understanding of the basic mechanisms underlying Thyroid Hormone action in the nervous system. Our results indicate that profound changes are occurring in the neuro-muscularjunction after the acute inhibition of Thyroid Hormone synthesis. These changes include membrane electrophysiological properties, protein metabolism and animal behavior.

Serguei Skatchkov, Ph.D.
Polyamine Fluxes via Hemichannels in Glia: Neuronal Network Regulation
Comparing astrocytes with HeLa cells expressing connexin-43 (HeLa-Cx43-eGFP) hemichannels, we have demonstrated that SPM permeates the cell membrane of astrocytes via connexin43 hemichannels and can potentiate opening of these hemichannels. Furthermore, we have shown that SPM released from astrocytes can mediate changes in synaptic activity.

 

Administration

Program Director
Luis Cubano, Ph.D.
luis.cubano@uccaribe.edu
787-798-3001 x2150