Suranganie Dharmawardhane

Adjunct Associate Professor
Ph.D. 1987, University of Massachusetts, Amherst, MA

Academic Department(s)
Anatomy and Cell Biology

Research Area
Cell and Molecular Biology

Research Interest
Resveratrol in breast cancer cell survival or apoptosis
Role of soy phytoestrogens in breast cancer progression

Selected Publications
Rapid quantification of resveratrol in mouse plasma by ultra high pressure liquid chromatography (UPLC) coupled to tandem mass spectrometry.  Castillo-Pichardo L, Dharmawardhane S, Rodríguez-Orengo JF. PR Health Sci J. 2014 Dec;33(4):151-6.
The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. Castillo-Pichardo L, Humphries-Bickley T, De la Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S. Transl Oncol. 2014 Oct 24;7(5):546-55.
Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice. Castillo-Pichardo L, Cubano LA, Dharmawardhane S. BMC Complement Altern Med. 2013 Jan 8;13:6
The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G. de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S. J Biol Chem. 2012 Dec 7;287(50):41640-50.
Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Castillo-Pichardo L, Dharmawardhane SF. Nutr Cancer. 2012;64(7):1058-69.

Contact Information
Universidad Central del Caribe
P.O. Box 60327
Bayamón, PR 00960-6032

Tel:  (787) 798-3001 ext. 2152